Thursday, July 3, 2014
Newly Discover Ribosome Might Lead To Cancer Treatment
Scientists recently found the “missing link’’ of chemical systems enabling animals cells to produce ribosomes and manufacture the entire proteins necessary in building tissues and sustain human life. This discovery provide venue for scientists to better understand the process of limiting the uncontrolled growth of cells especially cancer cells that somehow be regulated through controlling the release of ribosomes.
Ribosomes are mainly responsible in producing wide variation of proteins such as structural molecules, enzymes, skin, hair, and bones, hormones (insulin), and immune systems components (antibodies). Though, ribosomes serve as essential molecular machines that undergo intensive study by various scientists. Until now, researchers haven’t uncovered yet the overall details on how proteins used in constructing ribosomes are produce.
In the multicellular animals especially humans, the ribosomes are created for an approximate 80 variation of proteins (humans comprises of 79 and some animals feature slight number variation) and four different RNA molecules classification. Previously, scientists discover that ribosomal RNAs synthesis is carried through systems specialization with the mere use of two key enzymes that includes RNA polymerase I and the RNA polymerase III.
As of now, scientist’s still unsure if the "complementary systems" responsibly produces 80 proteins in the creation of ribosome. Jim Kadonaga a biology professor from University of California, San Diego leads this study in examining the ribosome. In the study that the missing link particularly the specialized systems permit ribosomal proteins to undergo in cell synthesised.
Kadonaga said this ribosomal proteins findings undergo synthesised thru the regulatory novel systems together with enzyme RNA polymerase II and some factors known as TRF2. In the production of protein, RNA polymerase II work closely with certain factors namely TBP. But in ribosomal protein synthesis, TRF2 is entirely use.